Appendix A

Previda® ER Plus: Comprehensive Study of the Endometrium. Microbiome Study, Endometrial Receptivity & Microbiome

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A genomic test that quantifies the expression of relevant genes regulated by hormones to determine
the best timing of the implantation window for a patient, thus increasing the probability of achieving
pregnancy. The implantation window is the period during which the endometrium is in optimal
conditions to accept a high-quality embryo for implantation. This typically occurs between 8-10 days
after ovulation in a natural menstrual cycle or 5.5 days after progesterone exposure in an assisted
reproductive cycle. This test is recommended for patients with implantation failures, adenomyosis,
availability of a single embryo for transfer, or unexplained infertility.
It allows us to personalize embryo transfer during the optimal endometrial timing
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A functional diagnostic test that quantifies the reproductive microbiome and its relationship with
infertility and subfertility. It involves analyzing different microorganisms that form part of the
reproductive ecosystem, such as Lactobacillus crispatus, Lactobacillus jensenii, Lactobacillus iners,
Lactobacillus gasseri, Candida albicans, Candida glabrata, Atopobium vaginae, Gardnerella vaginalis,
Trichomonas vaginalis, Enterobacteria, among others. This test not only analyzes the percentage of
lactobacilli but also identifies and quantifies various species that may cause a Lactobacillus dysbiosis
leading to endometritis. It is the only test that identifies the entire range of microorganisms (bacteria,
protozoa, fungi, and viruses) with the highest diagnostic rate in the market. Additionally, it is
complemented with Metabolic Activity Markers that evaluate the impact of these imbalances on the
endometrial tissue.
It allows us to modulate the endometrial microenvironment to improve endometrial functionality
using approved supplements and pharmacological treatments.